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Telomeres have very strong relation to age related diseases such as cancer, diabetis, alzheimer’s, cvd’s. Telomere shortening is a major cause of cellular aging and this leads to tissue and organ aging. Below graphic shows clearly telomere shortening is one of the major cause of diseases.
Best strategy to prevent these diseases is to prevent the telomere shortening. This will lead you not only to healthspan but also lifespan as well. In order to keep the telomeres as long as possible you may chose a healthy life style as well as consult to your anti-aging doctor how to slow down the aging. But there are some tips you may follow:
According to statistical data gathered from TA-65 users more than 6 month provides significant improvments as shown below chart. Numbers are the % of patients declares particular benefit.
According to a study published in the January 2011 issue of Nature journal, premature aging can be reversed by reactivating telomerase, the enzyme that lengthens telomeres. The study offers the possibility that normal human aging could be slowed by activating the telomerase enzyme in cells where it has stopped working. Researchers studied mice that were artificially aged by switching off the telomerase enzyme. The mice experienced weakened organs, infertility, grey hair, dermatitis, other age-related conditions, and early death.
"Ifyou look at all those data together; you walk away
with the idea that the loss of telomerase could be very
important instigator of the aging process,"
according to Harvard Professor Dr. Ronald DePinho.
However, when the telomerase enzyme was switched back on, the mice became younger. Researchers saw a dramatic reversal in the signs and symptoms of aging with telomerase activation. Benefits included increased brain size, improved cognition, restoration of hair to a healthy sheen, restored fertility and recuperation of organs (spleen, liver, intestines).
The most important lesson learned from this study is that aged tissues, even ones in an advanced state of degeneration retain a remarkable capacity to renew themselves and telomerase, when activated, can reverse certain aspects associated with aging.
In the largest and most diverse study of aging to date, telornere length is being analyzed as a marker for age-related conditions. This genomic project, Genetic Epidemiology Research on Adult Health and Aging (GERA), aims to increase understanding of the genetic basis for a host of problems.
Funded by the National Institutes of Health, the project includes a wide scale genotyping project incorporating longitudinal clinical and health data. After adjusting for the range of demographic and behavioral factors that influence telomere length (age, sex, race, education, physical activity, BMI, smoking, and alcohol consumption). there was a significant relationship between individuals with the shortest telomere length and increased mortality.
"We found that individuals whose telomeres were in the shortest 10 percent were about 23 percent more likely to die in the three years following measurement of their telomeres, when compared with Individuals whose telomeres were longer," said lead study author Catherine Schaefer, director of the Kaiser Permanente research program on genes, environment and health.
The large cohort of 100,000 individuals demonstrates the importance of telomere length and health and provides the foundation ror continued studies on the pathways linking telomere biology and longevity.